Gymnema sylvestre extract CAS 90045-47-9

Specification

Application

1.Hypoglycemic effect

Gymnema sylvestre extract has a mild effect on normal blood sugar, but when used in combination with glucose or sucrose, it can significantly inhibit the increase in blood sugar levels and significantly reduce the secretion of plasma insulin.

2. Hypolipidemic and anti-atherosclerotic effects 

Gymnema sylvestre leaf extract can reduce the levels of serum triglycerides, total cholesterol, very low-density lipoprotein-cholesterol and low-density lipoprotein-cholesterol in hyperlipidemic rats, and restore the low high-density lipoprotein-cholesterol and anti-atherosclerotic index in hyperlipidemic rats. 

3. Inhibition of sweet taste response 

Gymnema sylvestre may inhibit sweet taste response by blocking the sweet taste receptors on the surface of taste cells. Gymnema acid is the main component of sweet taste inhibition. The presence of phthalide plays an important role in inhibiting sweet taste response and can cause taste loss. The inhibition rate of 8 sweeteners such as fructose, sucrose, stevioside, and xylitol is 77%. The polypeptide gurmarin can significantly inhibit the sweetness of lactose, maltose, saccharin, etc., with an inhibition rate of 40%-50%. 

4. Anti-caries effect 

Caries is caused by the transformation of glucose into water-insoluble glucan by streptococci in the oral cavity, which adheres to the enamel on the surface of the teeth. Gymnemic acid can significantly inhibit the activity of glucosyltransferase, block the synthesis of extracellular water-insoluble glucan of mutans streptococci, inhibit the formation of dental plaque, and make cariogenic bacteria lose the cariogenic environment, thereby achieving an anti-caries effect. 

5. Weight loss effect 

Gymnemic acid (GA) has the effect of weight loss because GA can reduce the body's absorption of sugar in addition to reducing the desire for sweets. GChemicalbookA reduces the desire for sweets by reducing the sweetness of food, but does not make it completely without sweetness. This effect can last for 1-2 hours. Inhibiting the absorption of sugar is to control the absorption of sugar molecules by the intestine during digestion, which can effectively reduce the metabolism of sugar, thereby changing the absorption of sugar, thereby achieving the effect of changing blood sugar content. 

6. Anti-tumor and anti-inflammatory effects 

The primary characteristics of tumors are malignant proliferation and imbalance between cell proliferation and apoptosis. Anti-proliferation and promotion of apoptosis are effective strategies for treating tumors. In vitro, gymnemagenol in Gymnema sylvestre can inhibit HepG2 cells (human liver cancer cells), and Gymnema sylvestre extract has significant anti-breast cancer and lung cancer epithelial cell activity. 

7. Antioxidant and anti-radiation effects 

Studies have found that the mechanism of Gymnema sylvestre's antioxidant effect is to inhibit DPPH free radicals and scavenge superoxide and hydrogen peroxide groups to exert antioxidant effects. The effective antioxidant components of Gymnema sylvestre may be related to compounds such as flavonoids, phenols, saponins and triterpenes in Gymnema sylvestre. 

8. Antibacterial and antiviral effects 

Studies have been conducted on the inhibitory effects of Gymnema sylvestre extracts on microorganisms such as bacteria and fungi, and it has been found that natural saponins and purified saponins at different concentrations have significant antibacterial effects. 

9. Immunomodulatory effects 

Gymnema sylvestre water extracts show activity on human neutrophils and have good immunomodulatory effects. 10. Other pharmacological effects

Gymnema sylvestre crude extracts can effectively kill the larvae of mosquitoes that can transmit malaria and filariasis. It is a natural insecticide and has no toxic effects on the environment.

Storage

Room temp