Isopropylamine

Isopropylamine is abbreviated as IPA or MIPA. It is a colorless, hygroscopic liquid with an ammonia-like odor and is flammable. It is widely used in the production of pesticides, such as isopropylamine is an important intermediate for the production of methyl isothiophene phosphide, thiazinone, atrazine, etc., and is also widely used in the fine chemical industry, such as in the production of detergents, rubber, and medicine, etc.

Nature

Isopropylamine can undergo condensation reactions with aldehydes. For example, when reacting with benzaldehyde, it forms N-phenylmethylisopropylamine; it can also react with acyl chlorides. For instance, when reacting with 4,4'-dichloro-biphenyl in the presence of triethylamine, it generates N,N'-diisopropyl-4,4'-dichlorobiphenyl.

It is a base and can react with acids:

C3H9N + HNO3 → [C3H9NH]NO3

C3H9N + HCOOH → [C3H9NH]HCOO

Synthesis

The synthesis method of isopropylamine is characterized by: a preheater is set before the fixed bed reactor, and an air-liquid separator is set after the fixed bed reactor; quartz sand is filled at both the inlet and outlet ends of the fixed bed reactor; a mixed catalyst is filled in the middle section of the fixed bed reactor, using acetone, hydrogen, and ammonia as raw materials, to synthesize isopropylamine through acetone reduction and ammoniation. The reaction conditions are: the reaction pressure is from atmospheric pressure to 0.4 MPa, the reaction temperature is 80 to 130 °C, the molar ratio of acetone, hydrogen, and ammonia is 1:3:4 to 4.6, and the liquid space velocity of acetone is 0.1 to 0.5111.

The mixed catalyst is obtained by uniformly mixing a nickel-based catalyst with quartz sand in a ratio of 2:0.8 to 1.2 by mass; the quartz sand in the mixed catalyst and the quartz sand packed at the inlet and outlet of the fixed-bed reactor are all post-treatment quartz sand prepared by the following method: 40-60 mesh quartz sand is baked at 800°C for 24 hours and then cooled to room temperature to obtain the post-treated quartz sand.