Ethyl 2-bromopropionate Usage And Synthesis

Structural characteristics: 

Ethyl 2-bromopropionate contains an ester group and a highly reactive bromine atom in its structure. The bromine atom in its structure can be attacked by nucleophilic reagents to generate corresponding addition products. For example, it can be attacked by triphenylphosphine to obtain the corresponding Wittig reagent.

Chemical properties: 

Colorless liquid. Has a strong pungent odor and turns yellow when exposed to light. Miscible with ethanol, ether, and chloroform, insoluble in water.

Application: 

Ethyl 2-bromopropionate is often used as an intermediate in organic synthesis and pesticide molecule synthesis. It is mostly used in the production and preparation of pesticide molecules. For example, it is a key synthetic intermediate for the pesticide molecule herbicide quizalofop-p-ethyl.

Use: 

Used as a special synthetic intermediate for the herbicide quizalofop-p-ethyl.

Ethyl α-bromopropionate is an intermediate of herbicides such as quizalofop-p-ethyl, oxazolidinone-methyl, fosthiazolin-p-ethyl, fluazifop-p-ethyl, lactofen-p-ethyl, isopropylamine, and propamide, and fungicides such as metalaxyl, bensulfuron-methyl, and procymidone.

Used as a solvent and also used in organic synthesis.

Production method: 

The preparation method is to put propionic acid and red phosphorus into a reaction bottle, add bromine dropwise at 60℃ for about 3 hours, heat to 100-120℃, keep warm and stir for 6 hours, cool, filter, heat and distill the filtrate, and then fractionate to obtain 2-bromopropionyl bromide, and react 2-bromopropionyl bromide with anhydrous ethanol to obtain the finished product. The reaction equation is as follows: CH3CH2COOH+Br2[P]→CH3CHBrCOBr+H2OCH3CHBrCOBr+C2H5OH→CH3CHBrCOOC2H5+HBr

Propionic acid reacts with thionyl chloride and bromine to obtain 2-bromopropionyl chloride ([7148-74-5]), which is then reacted with ethanol to obtain this product.