Application of Benzyl chloride CAS 100-44-7

Introduction

Benzyl chloride, also known as benzyl chloride or chlorotoluene, is a colorless liquid with a strong irritating odor. It is miscible with organic solvents such as chloroform, ethanol, and ether, and does not dissolve in water but can volatilize along with water vapor. Its vapor has a certain irritant effect on the mucous membranes of the eyes and is a very strong tear-inducing agent. At the same time, benzyl chloride is also an intermediate in organic synthesis and is widely used in the production of dyes, pesticides, synthetic fragrances, detergents, plasticizers, and medicines.

Application

Chlorobenzyl chloride is widely used in industry, mainly in the fields of pesticides, pharmaceuticals, fragrances, dye auxiliaries, and synthetic auxiliaries. It is used to develop and produce products such as benzaldehyde, butyl benzyl phthalate, aniline, parathion, benzyl penicillin, benzyl alcohol, benzyl cyanide, benzyl acid, etc. Chlorobenzyl chloride belongs to the irritating compounds of halogenated benzyl. In pesticides, it can not only be directly used to synthesize organophosphorus fungicides such as rice blast nettle and isoblast nettle, but also can be used as an important raw material for many other intermediates, such as synthesizing benzyl cyanide, benzoyl chloride, ortho-phenoxybenzaldehyde, etc. Moreover, chlorobenzyl chloride is widely used in medicine, fragrances, dye auxiliaries, synthetic resins, etc. It is an important chemical and pharmaceutical production intermediate. Then, in the production process of enterprises, the waste liquid or waste generated inevitably contains a large amount of chlorobenzyl chloride intermediates.

It is an organic synthesis intermediate and is widely used in the fields of medicine, pesticides, fragrances, dye auxiliaries, synthetic resins, etc. The main derivative products of benzyl chloride are as follows: (1) Benzyl butylamine: It is obtained by the reaction of benzyl chloride and tert-butylamine. (2) Butyl benzyl phthalate (BBP) : Firstly, phthalic anhydride reacts with butanol to form butyl phthalate, and then it continues to react with sodium hydroxide to form sodium butyl phthalate salt. The sodium salt then reacts with benzyl chloride to form BBP. It is widely used as the main plasticizer for PVC plastic products. (3) Benzyl alcohol: It is obtained by heating and hydrolyzing benzyl chloride in the presence of an alkali. It is one of the important derivatives of benzyl chloride. It is a fine chemical product with a large tonnage. Benzyl benzoate, benzyl acetate and benzyl propionate prepared from aromatic alcohols can be used as fragrances, solvents, etc. (4) Benzyl quaternary ammonium salts: for example, dodecyl dimethyl benzyl ammonium chloride (Benzyl chloride), dodecyl dimethyl benzyl ammonium bromide (Benzyl chloride). Benzyl quaternary ammonium salt cationic surfactants are mainly used as disinfectants, hydrophobic agents, corrosion inhibitors, deemulsifiers and phase transfer catalysts. (5) Acetonitrile: It is obtained by the condensation of benzyl chloride and sodium cyanide and is one of the important derivatives of benzyl chloride. It is mainly used in the production of pesticides such as phoxim, ethyl Rice Powder, and medicines such as Kebiqing and dibrazole. A series of intermediates prepared from acetonitrile have many important uses. For example, phenylacetic acid, phenylacetaldehyde, o-ethylbenzoic acid, ethyl 2-chlorophenylacetate, phenylethylamine, α -phenylacetamide, ethyl phenylacetate, β -phenylethanol. (6) Diphenylmethane: It is obtained by the reaction of benzyl chloride with benzene in the presence of an aluminum amalgam catalyst and is used in organic synthetic materials. Diphenylmethane is oxidized with nitric acid to produce benzophenone, which is mainly used as an ultraviolet absorber and a pharmaceutical intermediate. (7) p-chlorobenzyl chloride: It is obtained by low-temperature chlorination of benzyl chloride and is used for further preparation of p-chlorobenzyl alcohol, p-chlorobenzaldehyde, p-chlorobenzonitrile, p-chlorobenzic acid, p-chlorobenzomethane, and p-chlorobenzyl chloride. It is mainly used in pharmaceutical production. (8) Dibenzyl sulfide: It is obtained by the reaction of benzyl chloride with sodium sulfide and is used in organic synthesis. (9) N-methylbenzylamine: It is produced by the reaction of benzyl chloride with -methylamine in benzene solvent and is used as a pharmaceutical intermediate. (10) Benzylamine: It is obtained by the reaction of benzyl chloride with urotropine or ammonia water. It is synthesized by the reaction of benzylamine with formaldehyde and formic acid to form N, N-dimethylbenzylamine, which is the raw material of benzylamine. (11) Dibenzylamine: It is obtained by the reaction of benzyl chloride with liquid ammonia in ethanol and is used in organic synthesis. (12) S-benzyl isothiourea: It is obtained by the condensation of benzyl chloride and thiourea and is used as a reagent and raw material for organic synthesis. (13) Benzyl cinnamate: It is obtained by the reaction of cinnamic acid with benzyl chloride or methyl cinnamate with an excess of benzyl alcohol. It is used as a fixative and modifier for fragrances. (14) Benzyl o-hydroxybenzoate: It is produced by benzyl chloride, sodium o-hydroxybenzoate and dimethyl sulfoxide, and is an important intermediate in the production of fragrances. (15) Benzaldehyde: It is obtained by the acid or alkali hydrolysis of benzyl chloride and is one of the important derivatives of benzyl chloride. It is used for the production of cinnamic acid, cinnamaldehyde, α -amyl cinnamaldehyde, α -ethyl cinnamaldehyde, benzophenone, etc.